Pair Name	Beta-Elemene, Oxaliplatin
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Biological Phenomena	Induction-->Cellular uptake
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Expression	BECN1	hsa8678
	Up-regulation	Cleavage	CASP3	hsa836
	Up-regulation	Expression	MAP1LC3A	hsa84557
	Down-regulation	Phosphorylation	MAPK3	hsa5595
	Up-regulation	Cleavage	PAEP	hsa5047
In Vitro Model	MHCC97-H	Adult hepatocellular carcinoma	Homo sapiens (Human)	CVCL_4972
	HCCLM3	Adult hepatocellular carcinoma	Homo sapiens (Human)	CVCL_6832
In Vivo Model	Human HCC cell line MHCC97H were used to estabolish xenograft models in the BALB/c mice.
Result	Our findings show that β-elemene can block the reduction of CTR1 resulting from oxaliplatin treatment, and therefore has a synergistic anti-HCC effect with oxaliplatin by enhancing cellular uptake of oxaliplatin. The synergistic effects of β-elemene and oxaliplatin deserve further evaluation in clinical settings.